Problem with Speaker Configuration in Audio Midi Setup

[HB123]

I'm hoping someone can help here, as I've seemingly tried everything.

In Audio Midi Setup, I'm trying to change my speaker output configuration. (I'm using HD Native w AVID i/o interfaces, and would like the audio to come out of outputs 25&26 instead of the default 1&2)

When I press the test buttons, I can hear white noise, BUT no core-audio will come out of the speakers. No iTunes, no Quicktime… they continue to come out of 1&2… Furthermore, when I quit Audio Midi Setup, my speaker configuration does NOT save, and instead defaults to outputs 1&2.

I've seen others online with this problem, but no solutions.

Anybody?

Thanks!