I'm having the same issues with Kontakt and similar issues with SampleTank 4.
It seems like it's when Pro Tools VI's are trying to load samples in to the plugin it just crashes with spinning/frozen beachball. Both works perfect in standalone mode.
I'm in contact with IK Multimedia support, but they solved it yet.
Hope for a quick fix soon
I'm on a new MacBook Pro 2021 16" M1 Pro , 16GB Ram, 1 TB SSD.
Mac OS Monterey 12.0.1, Pro Tools 2021.10