Depends on which 192. If its a 192Digital, which only has digital IO, then it should work for all 16 channels of the A16. If its a 192 that is half&half(8 analog IO and 8 digital IO), then you might only be able to do 8 via lightpipe. But, having said that, there are 2 lightpipe ports on the back of my 192(1 set on the IO card and another near the power and wordclock ports), so MAYBE you can configure it to do all 16 digital. The key to success will be going(in Pro Tools) to Setup>Hardware and properly configuring the 192(which can be a bit daunting). As already said, you will be limited to 48K with lightpipe into the 192