[_JJ_]

Like the iLok, your Duet is a USB 2.0 device so the cable that came with it is the one to use.

I believe your iMac has 4 USB 3.0 ports plus two Thunderbolt ports? I would suggest connecting your audio drive directly, hopefully it is a 3.0 device (or better yet a TB drive) so it could take full advantage of that speed.

I would also connect your Duet directly to a 2nd port. Even thought it's 2.0, passing through the hub is just another unknown.

Then your hub could easily handle your iLok, keyboard, trackball, whatever else is not speed dependent.