Depends on the interface(hardware and software, if applicable). This is where experience and ingenuity will help you decide how to route audio to accomplish this. For instance, in my setup(DIGI003) I feed the main send to the headphone amp(so everyone gets the main mix) AND I can add(with AUX sends) "more me"(or more whatever) to each of the 4 headphone mixes. My dilemma was, how can I(the engineer) solo anything without interrupting the main mix(that is the basis for all the headphone mixes)? My solution was to add a send to every track(all at -0, all in Pre-fade, and all disabled and built into my session template). If I want to solo anything, I switch my monitor controller(Presonus Central Station) to a different input(what those sends feed) and enable the send(Ctrl-click). So, with a Ctrl-click, instead of a mouse click only, I can solo for me, without affecting the main mix feeding the phones. Figure out what works with your equipment