[ScorpioNC]

Sounds like you either need to setup your I/O, or you possibly have another M-Audio interface attached at the same time.

If you have another M-Audio device, you will need to remove it before starting Pro Tools. Pro Tools can only use one audio interface at a time (with only a few exceptions).

Pro Tools needs to recognize an audio interface to open at all, so if you don't have another M-Audio device, then the PMIO is being recognized, and you probably just need to setup your I/O.

Go to Setup->I/O... and click he default button on each tab (input, output, insert, bus).

The only other thing I have M-Audio is a Radium 61 Keyboard. Would that interfere? How would I use any Soft Synths?