Just an idea you probably done already so just Checking:
Darryl has many great points as usual so I am not trying to retype anything he said or butt in so these are just a few simple basic tests that takes a minute to make sure
Trash the preferences and restart everything and see if that helps and make sure that you have the 003 as the playback interface under the hardware dropdown menu. We had PT default to one of our 49 inch ASUS Curved monitor after a crash once and not our Avid Carbon interface on one of the studio rooms a few times and didn’t realize this for a few minutes so just an idea. Maybe PT tries to use the ASIO thats why i posted the check that it is the 003 as the sound device.
When trashing preferences PT sometimes fixes weird issues like this one.