[JFreak]

In theory, yes. Less plugins means better sound, especially true with floating point mixers.

But for example if you want to use Sonnox Inflator in your final master, then you will use Sonnox Inflator in your final master even though most of your processing would be iZotope. And sometimes decisions like this make using a suite plugin impractical as that may mess up the order of processing you want to do.