Re: Can I do this to a late 2012 iMac?
To me it hardly seems worth opening up one of these to just put a SATA SSD in it, with all that work I'd want to upgrade the PCIe SSD to as large as it goes (1TB?). You have to check with OWC or others if they have a PCIe SSD that works for that. And being old it will likely be a 4 x PCIe 2.0 or 2 x PCIe 3.0 but not the 4 x PCI 3.0 on modern drives... but that's still much faster than SATA. The SATA one is trivial in comparison and sure I'd replace the SATA HDD if the iMac is open.
I'd just get the iMac running and see how it goes with Pro Tools before doing brain surgery. Before cracking the iMac open upgrade DRAM if needed, split the fusion drive, do a full clean macOS install on the HDD or SSD if you have enough space there, and use external drives if needed, the models I already mentioned. Velcro them to the back of the iMac....
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