[myfm]

I don't know if this will help, but there should be a little utility included with the PTLE CD called MMERefresh.exe, which refreshes the midi ports. This is a problem I've only seen with the 002 but it might work. If you do a Ctrl-Alt-Delete and check Windows Task Manager, you might see MMERefresh.exe already there

You might be able to find MMERefresh.exe at the Digidesign site too.

You might be having a conflict with the onboard sound card if your motherboard has it. I would suggest disabling the onboard sound card and see if PTLE works properly then.