Hi welcome to DUC.
Please take time to search for know issues before starting yet another thread about frequently reported stuff. And yes this horrible very cryptic error message is stupid and reflects just engineering/product management laziness on Avid's part...
But this has been answered hundreds of times on DUC, the "strange" meaning has been explained many times as well, by me and others, the assert message is not referring to your E drive... its referring to the E drive path where the Pro Tools source code was when Pro Tools was built.
Had you googled the error you would have found this KB article
https://avid.secure.force.com/pkb/ar...t-cpp-line-822
But should trying addressing the playback engine issue does not fix this, come back here describing what you tried/what happened. And include info on what exact audio interface you have and what exact driver you have installed for it... I personally would not use any interface that does not have a native ASIO driver, and you want your PC set up so only Pro Tools is using that interface and Windows and other apps all use a separate Windows sound device ie. your PC built in sound card.