[Darryl Ramm]

Thanks for being proactive with the Sandra report, nothing there jumps out (except Kaspersky AV software which you should disable or even better IMNSHO remove every last part of that crapware).

Pro Tools version? (it's hard to know wether to signature files are accurate/up to date).

What exact interface driver are you using? ASIO4ALL or the native ASIO driver? (you should be using the native driver). What exact driver version is installed and what exactly is the playback engine set to? (don't assume go look/provide a screenshot).

Don't have Windows set to use the interface at all, just Pro Tools.

Your session sample rate is? IO buffer size is?

You are recording to what drive? (double check the session really is recording audio files to your Glyph external drive).

If on Pro Tools 12? Is disk Cache enabled? Set it to a size not "standard".

Is your system fully optimized? What other standard troubleshooting have you tried? Trashing prefs? Starting with a new empty session. etc.