PC's are very fussy with USB interfaces. I had your same problem with a USB extender cable between computer and my MBox2Mini and the desktop. As soon as I plugged the Mini directly into the 'front' USB hub the problem went away. I even had intermittent clicking when I plugged it into the BACK USB reports that disappeared when plugged in to the 'front' USB ports. Uggh.
On a laptop you only have a couple USB options.
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Rig 1-Mix/Mast: PTHD 11.3.1; MacPro 6core (6,1) 3.5 GHz Xeon E5; 10.10.3 (SSD Drives for audio); Apogee DUET, FireStudio2626 as Hware Inserts to PT for outboard
Rig 2-Cutting&Remotes: PTHD 11.3.1; MacBook Pro (8,1) 2.8 GHz Dual i7; 10.9.2 (128GB int '6G' SSD drive); Profire LightBridge (FW800), 32ch Presonus Digimax FS
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