I am also having this issue. I just got a Saffire 56. I have a project which is on 44.1k, Mix Control sees it fine. But when I close and open a project in 48k, I get the clock error message. I do a restart of PT and the 48k project plays fine. Close and reopen the 44.1k project. Clock error! I had no issues with this when I used an Mbox. Very frustrating I have to restart PT to open a file.