I use the SPDIF IO on my 003 all the time. I have a DBX-386 preamp feeding the SPDIF input(my 003, ISA428 and the DBX are all clocked via wordclock from a Lucid GenX 192 master clock). And the SPDIF output feeds the RCA digital input of my Presonus Central Station. As I said above, clocking must be done correctly or you will have troubles. BTW, my rig runs both 10 and 11