You will likely get lots of opinions on this, so here's mine
1-Cost not an object? Buy a Kemper Profiler. Its killer in the hands of any reasonably talented player.
2-Eleven Rack is a decent piece but quite limited next to the Kemper. It CAN also be your interface, but its also on the "old" side of these things.
My 2nd choice for hardware would likely be the Headrush Pedalboard. It takes the Eleven Rack platform up several notches, and its cheaper than the Line 6 Helix(which also can sound really good)
3-there are lots of software options and most any is capable of sounding great in a mix. They are also equally capable of sounding like crap. The difference comes down to the player and your willingness to put the time into tweaking the hundred things that are tweakable.
4-if you already have some pedals, a Fender Deluxe Reverb with ribbon mic can cover a lot of ground(if you can work with a live amp). Alternately, the Fender Super Champ XD head into a Palmer speaker load box......(yeah, there really are way too many options
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