As to the Focusrite sample rate back and forth. I am poor! The 2i4 first generation is my only option, I'm Windows 10, 64 bit with Pro Tools 12.7. I have found that setting all sessions to 16 /44 is the ultimate answer to the problem of trying to find a solution that doesn't exist. It works for me. That's the way music winds up anyway and I argue that there is all that much noticeable difference in the sound quality unless your one of those fortunate people with super hearing!