For me, troubleshooting would likely be as follows:
1-shut down everything
2-re-seat every card in the computer
3-re-seat all RAM sticks
4-re-seat every cable(both ends) that connect any device(USB, FW and MIDI)
5-re-test
6-if no improvement, update drivers for graphics and MOTU
7-if no improvement, come back and see if anyone has more ideas