The only thing I'm not sure about is the latency when just going ethernet. They have an optional PCIe card that gets under 3ms, but I'm not sure what the latency is when not using that. I guess it would be no worse than firewire or usb, though.
The other thing is I'm not clear about what kind of preamps are in the 8 preamp module. Not sure if it's ISA range, Red range, or some new design.
Also, none of the modules have an monitor control. It looks like they're assuming you will use your own choice of monitor controller.
Here's a video with Paul White interviewing them at NAMM:
http://www.soundonsound.com/news?NewsID=13521