Re: Mbox 3 pro and windows 10 pc
FWIW, I'm quite happy with a Presonus Studio 1810c connected via USB3(can also do USB-c). They have several models in the range with more or fewer IO, so you might find one that suits your needs without busting your wallet.
Re the PCI slot, the old PCI protocol is pretty much dead and buried and we now get PCI-e(way faster and better, but not compatible with PCI).
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Gigabyte X79/intel i7 3930K, 32GB RAM, Presonus Studio 1810C
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