Re: Mbox 2 Family - Win10
2 things jump out right off the bat
#1-with Windows machines, go into Sound>Properties and make sure that Windows is NOT using the interface as its default playback device(leave the interface for Pro Tools, only)
#2-any time something is not "right", the first thing I would try would be to run everything at stock speeds(right now, you are overclocked to 5GHz and basic troubleshooting calls for eliminating as many variables as possible).
After that, review and verify all Windows tweaks, including disabling Power Management on all USB ports (but my money is on the sound.properties setting)
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