Indeed^^^ Pick your chipset(like X99, X399, etc) and you might consider going with a Gigabyte mobo as Avid's current recommendations don't support Asus. Now, "not supported" doesn't mean "won't work", but since you are starting from scratch, why tempt fate
Having said that, for myself, I had lots of errors and issues with my Asus X99 rig, but my older Asus X79 system is humming along nicely with the current version of PT Ultimate