Re: 2019.5 Ultimate on a Mac Pro 5,1
Oh come on, please don't upgrade Pro Tools in the middle of a project if there is not a serious problem you are trying to solve. Have you rolled back to what you had before that was working? Hopefully that is a quick reboot away or reinstall of Pro Tools.
If there is a reason you need to stay on 2019.5 you need to troubleshoot...
Trash prefs
If you had hyperthreading disabled to run 2018 on Mojave try turning it back on. (oops I guess you did not move to Mojave from your signature)
If you had dynamic plugin processing disabled, try turning it back on (it does seems to help more now).
Make sure your disk cache is on, set to several GB at least, disk IO happening can help trigger a -9173 (seemingly more so than a -6101).
Presumably you are mixing and already maxed out your IO buffer size and maybe already freezing tracks?
Check the system is fully optimized etc.
Troubleshoot plugins....
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